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This study is to evaluate the effects of preoperative carbohydrate intake on perioperative neuroinflammation and development of delirium.
Perioperative insulin resistance may primarily contribute to development of postoperative delirium in high risk patients. Preoperative administration of oral carbohydrate reduces insulin resistance. The investigators aimed to investigate the influence of carbohydrate loading on the serum level of S-100β, a surrogate marker of delirium, and the incidence of postoperative delirium in elderly patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Allocated to Carbohydrated group | Experimental |
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| Allocated to Placebo group | Placebo Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Allocated to Carbohydrated group | Dietary Supplement | Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal. |
| Measure | Description | Time Frame |
|---|---|---|
| serum S-100β level | Postoperative 1 hr |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D007249 | Inflammation |
| D003693 | Delirium |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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|
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| Allocated to Placebo group | Dietary Supplement | Patients received 400 mL of oral flavored water (Placebo) 12 hours before anesthesia and 400 mL 2 hours before |
|
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| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |