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The primary purpose of this study is to investigate the effects of carbohydrate-rich drink on postoperative nausea and vomiting in diabetic patients undergoing total knee arthroplasty. The secondary purpose is to investigate the effects of carbohydrate-rich drink on quality of recovery and inflammation in diabetic patients after total knee arthroplasty.
Carbohydrate-rich drink has been proved to neither delay gastric emptying nor affect gastric acidity and is therefore considered safe to use in elective surgical patients without risk factors for pulmonary aspiration. It reduced postoperative nausea and vomiting and improved sense of well-being after surgery. Moreover, carbohydrate-rich drink was not found to be affected by delayed gastric emptying in patients with uncomplicated type 2 diabetes. Therefore, carbohydrate drink may be safely administered 3 h before anesthesia without risk of hyperglycemia or aspiration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carbohydrate group | Experimental | Carbohydrate-rich drink 400 mL 3 h before surgery |
|
| Control group | Active Comparator | 10% dextrose solution mixed with insulin 16 unit 100 mL/h |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Carbohydrate-rich drink | Dietary Supplement |
| ||
| 10% dextrose solution mixed with insulin 16 unit 100 mL/h |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of postoperative nausea and vomiting | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Score of quality of recovery | Quality of recovery is determined by a 40-item quality-of-recovery questionnaire | 24 hours |
| Degree of inflammation | Degree of inflammation is determined by white blood cell count, neutrophil count, and C-reactive protein |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32433428 | Derived | Shin S, Choi YS, Shin H, Yang IH, Park KK, Kwon HM, Kang B, Kim SY. Preoperative Carbohydrate Drinks Do Not Decrease Postoperative Nausea and Vomiting in Type 2 Diabetic Patients Undergoing Total Knee Arthroplasty-A Randomized Controlled Trial. J Am Acad Orthop Surg. 2021 Jan 1;29(1):35-43. doi: 10.5435/JAAOS-D-20-00089. |
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| Dietary Supplement |
|
| 24 hours |