Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes

Stimulating the Production of Ketones Through the Combined Use of Aerobic Exercise (AE) and Dietary a Medium Chain Triglycerides (MCT) Supplement

The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes. After an evaluation of the metabolism (a 4-hour visit with multiple blood samples) at the beginning of the study, all the participants are taken for one-week the MCT supplement alone follow by a one-week period of taking the MCT supplement in combination with physical exercise. At the end of each period of time, the 4-hour visit for the evaluation of the metabolism is repeated.

Inclusion Criteria:

• Healthy women group: fasting blood glucose < 6.1 mmol/L and HbA1c < 6.0 %.
• Women with prediabetes: fasting blood glucose between 6.1 and 6.9 mmol/L and HbA1c between 6.0 and 6.4 %

Exclusion Criteria:

• Structured physical activity (more than 2 times per week)
• Inability to practice physical exercise
• Diabetes (fasting glucose ≥ 7.0mmol/L or HbA1c ≥ 6.5%)
• Uncontrolled dyslipidemia or hypertension
• Use of medications known to affect the metabolism of lipids and carbohydrates (steroids, beta-blockers, diuretics, insulin sensitizers, etc.)
• Severe infections or inflammations