Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants

Broccoli Sprout Dose Response: Bioavailability and Effects on Air Pollutants

This study will examine the extent to which lower doses of a broccoli-derived beverage enhance the detoxication of air pollutants excreted in urine as compared to an maximal dose shown to be effective previously.

This is a 10-day placebo control Phase II broccoli sprout intervention to be conducted in Qidong, P.R. China. Up to twelve hundred people from the farming townships will be screened and one hundred seventy eligible individuals will be enrolled in the study. Participants will be randomized into 4 treatment groups: one will receive a juice beverage containing a standard dose of glucoraphanin- and sulforaphane-rich broccoli sprout powder mixed in pineapple juice, lime juice and water, the second will receive one-half dose, the third one-fifth dose and the fourth group will receive placebo beverage containing pineapple juice, lime juice and water. Participants will drink their assigned beverage every evening and provide consecutive 12-hour urine collections throughout the duration of the study.

Inclusion Criteria:

• in good general health with no history of chronic illness
• normal liver function tests
• normal renal function tests

Exclusion Criteria:

• personal history of cancer except for non-melanoma skin cancer
• use of prescribed medicines
• for women, a positive pregnancy test