Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is to explore premeal protein-enriched bar effect in postprandial glucose levels and concentration of plasma incretin hormones [glucagon-like peptide 1 (GLP-1) and/or glucose-dependent insulinotropic polypeptide (GIP)] in healthy subjects and those with type 2 diabetes.
Fifteen healthy subjects and fifteen subjects with type 2 diabetes treated by diet and/or metformin, SU, DPP4 inhibitors will be recruited. Every subject will studied on 2 separate days in random order with 1-2 week intervals. These participants will consume protein enriched bar followed by a standardized high-glycemic-index breakfast in a hospital setting or breakfast followed protein enriched bar in a cross-over fashion. Blood sampling will be done at the moment of start of breakfast (0 min) and then 10, 20, 30, 60, 90, 120, 150, 180 min. Plasma glucose levels, total/active GLP-1, GIP, insulin, C-peptide, glucagon will be measured. Incremental area under the curve (iAUC) of glucose level and hormone from 0 min to 180 min will be calculated.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| premeal protein bar first | Experimental | intervention: premeal protein-enriched bar intake
|
|
| breakfast first | Other | intervention: breakfast follows by protein bar
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| premeal protein-enriched bar intake | Dietary Supplement | Premeal protein bar is provided 30 minutes before breakfast. Participants have to eat protein bar with in 5 minutes with 150ml of water. |
| Measure | Description | Time Frame |
|---|---|---|
| plasma glucose level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min | |
| Area under the curve (AUC) of plasma glucose level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| Measure | Description | Time Frame |
|---|---|---|
| plasma total/active GLP-1 level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min | |
| Area under the curve of plasma total/active GLP-1 level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
Not provided
Inclusion Criteria:
BMI 18.5~35 kg/m2
Healthy volunteer:
participants with diabetes
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Young Min Cho, MD, PHD | Associate Professor Division of Endocrinology and Metabolism Department of Internal Medicine Seoul National University College of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
Not provided
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| breakfast follows by protein bar | Other | Participants have to eat provided breakfast within 30 minutes. It is recommended for participants to eat protein bar shortly after finishing breakfast within 5 minutes. |
|
| plasma GIP level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| Area under the curve of plasma GIP level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| plasma insulin level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| Area under the curve of plasma insulin level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| plasma C-peptide level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| Area under the curve of plasma C-peptide level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| plasma glucagon level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |
| Area under the curve of plasma glucagon level after breakfast | -30 min, 0(breakfast), 10, 20, 30, 60, 90, 120, 150, 180min |