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The aim of this study is to explore premeal protein-enriched bar effect in food intake in healthy subjects.
Twenty healthy subjects will be recruited. Every subject will be randomized in 6 groups and studied on 3 separate days in random order with 1 week intervals. These participants will consume protein enriched bar, commercial cereal bar, or water followed by a standardized diet (gimbap). For study outcomes, food intake, appetite and satiety (visual analog scale), plasma glucose, and satiety related hormone will be measured. Blood sampling will be done before 15 min of breakeast, at the moment of start of breakfast (0 min), and then 30, 60, 90, 120 min. Plasma glucose levels, total/active GLP-1, ghrelin, total PYY will be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Experimental | protein enriched bar->commercial cereal bar->water |
|
| Group 2 | Experimental | protein enriched bar->water->commercial cereal bar |
|
| Group 3 | Experimental | commercial cereal bar->protein enriched bar->water |
|
| Group 4 | Experimental | commercial cereal bar->water->protein enriched bar |
|
| Group 5 | Experimental | water->protein enriched bar->commercial cereal bar |
|
| Group 6 | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein-enriched bar, commercial cereal bar, or water | Dietary Supplement | Protein enriched bar, commercial cereal bar, or water will be provided 15 minutes before breakfast. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Food intake | grams and caloric intake of standardized gimbap | 120min |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite (visual analogue scale : score 1 to 10) | (1: I am not hungry at all, 10: I have never been more hungry) | 120min |
| Satiety (visual analogue scale : score 1 to 10) | 120min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Young Min Cho, MD, PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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water->commercial cereal bar->protein enriched bar |
|
| plasma glucose (mmol/L) | plasma level of glucose | -15min, 0(breakfast), 30, 60, 90, 120 min |
| plasma active/total GLP-1 (pmol/L) | plasma level of active/total GLP-1 | -15min, 0(breakfast), 30, 60, 90, 120 min |
| plasma active ghrelin (ng/ml) | plasma level of active ghrelin | -15min, 0(breakfast), 30, 60, 90, 120 min |
| plasma total peptide YY (pg/ml) | plasma level of peptide YY | -15min, 0(breakfast), 30, 60, 90, 120 min |
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |