Combination Effect of Nefopam With Propacetamol for Postoperative Pain After Thyroidectomy

Patients undergoing thyroidectomy are suffering not only surgical wound pain but posterior neck pain because of neck extension position during the surgery. However, there has been little attention of posterior neck pain. Nefopam and Propacetamol have different pharmacodynamics and been used for postoperative pain control in thyroidectomy patients. The aim of this study is evaluation of combination effect of Nefopam and Propacetamol for acute wound pain, posterior neck pain and chronic pain after thyroidectomy.

Inclusion Criteria:

• patient who undergone open thyroidectomy
• 20~70 years old
• ASA I~III

Exclusion Criteria:

• hypersensitivity on Nefopam and Propacetamol
• Liver failure, chronic alcohol addiction
• severe hemolytic anemia, chronic nutrition deficiency
• history of seizure
• MI, MAO inhibitor
• pregnant, breast-feeding
• foreigners