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The goal of this study is to determine subjective gastrointestinal tolerance response and differences in breath hydrogen response following the consumption of two types of juice. This double-blind crossover study requires participants to arrive to the lab 12 hours fasted, consume 12 oz of juice and complete gastrointestinal tolerance questionnaires as well as produce samples for breath hydrogen analysis at various time points over the next 3 hours. Subjects will be asked to complete additional questionnaires at 12 and 24 hours post consumption, from home. Subjects will also be asked to keep a food record for 24 hours prior to their scheduled visit times to assure compliance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Apple Juice | Experimental | 12 oz apple juice |
|
| Grape Juice | Experimental | 12 oz grape juice |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| White grape juice | Other |
| ||
| Apple juice |
| Measure | Description | Time Frame |
|---|---|---|
| Change in gastrointestinal tolerance from baseline | Subjects will answer a 7 symptom questionnaire regarding the intensity of gastrointestinal symptoms experienced following juice consumption. Questionnaire is adapted from the validated Bovenschen gastrointestinal tolerance questionnaire. Questionnaire is to be completed at the following time points: baseline, 30 min, 60 min, 90 min, 120 min, 180 min, 12 hours, 24 hours. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Breath Hydrogen from baseline | Patients will be asked to exhale a full breath into a sample collection bag. The breath samples will be extracted and measured using the Quintron BreathTracker Analyzer at time points: baseline, 60 min, 120 min. This will be a marker of carbohydrate fermentation in the colon. | 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
• Use of enemas, laxatives, proton pump inhibitors, or antibiotics within the past 3 months
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Saint Paul | Minnesota | 55108 | United States |
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| ID | Term |
|---|---|
| D005518 | Food Preferences |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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