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The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of linear cutaneous surgery wounds improves scar cosmesis compared to wound closure with 5-0 fast absorbing gut.
The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of linear cutaneous surgery wounds improves scar cosmesis compared to wound closure with 5-0 fast absorbing gut. The investigators will use a split wound model, where half of the wound is treated with 2-octylcyanoacrylate and the other half is repaired with 5-0 fast absorbing gut. Three-months post-surgery, the scar will be measured via the physician observer scar assessment scale, a validated scar instrument. The scar width, and adverse events will also be recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Wound Closure with 2-octylcyanoacrylate | Experimental | One side of the patient's wound defect will be assigned to wound closure with 2-octylcyanoacrylate liquid bonding agent). |
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| Wound Closure with 5-0 Fast Absorbing Gut | Active Comparator | One side of the patient's wound defect will be assigned to wound closure with 5-0 fast absorbing gut sutures. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wound Closure with 2-octylcyanoacrylate | Procedure |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of Scar on the Patient and Observer Scar Assessment Scale | After surgical procedure, half of the subject's wound will be with 2-octylcyanoacrylate, while the other half is closed 5-0 fast absorbing gut sutures. After 3 months, subjects will return to clinic for evaluation of the cosmesis of both types of closure techniques. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of Scar Width | The width of the scar will be measured 1 centimeter from the midline on both sides. There is no defined width that is considered satisfactory or not satisfactory. The measurements will be compared between subjects. | 3 months |
| Assessment of Complications |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Eisen, M.D. | University of California, Davis | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31403536 | Derived | Zhuang AR, Beroukhim K, Armstrong AW, Sivamani RK, Eisen DB. Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis. Dermatol Surg. 2020 May;46(5):628-634. doi: 10.1097/DSS.0000000000002076. |
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| ID | Term |
|---|---|
| C100832 | octyl 2-cyanoacrylate |
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| Wound Closure with 5-0 Fast Absorbing Gut Sutures |
| Procedure |
|
Noting the presence or absence of bleeding, dehiscence, infection or spitting sutures. |
| 3 months |