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The goal of this study is to assess whether wound closure with skin adhesive or running stitches combined with skin adhesive will be superior to standard wound sutures. This is a split-wound study that will compare two methods of skin closure within one standard closure technique, thereby providing an internal control of running stitches within each wound. The investigators plan to measure outcomes by assessing for scar appearance, the incidence of wound opening, scar elasticity and subject satisfaction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Running polypropylene closure | Active Comparator | Half of every linear wound will be closed with running polypropylene sutures. This technique is Standard of Care. |
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| Tissue Adhesive (Derma-Bond) | Experimental | The experimental half of the wound will be randomized to receive closure with tissue adhesive alone. |
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| Subcuticular polyglactin-910 combined with tissue adhesive | Experimental | The experimental half of the wound will be randomized to receive closure with running subcuticular polyglactin-910 combined with tissue adhesive. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Running polypropylene closure | Procedure | Half of every wound will be closed with Standard of Care running polypropylene sutures |
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| Measure | Description | Time Frame |
|---|---|---|
| Wound Healing | The primary outcome measure of this study will be wound healing. This outcome will be assessed by the blinded observers, subject ratings and Cutometer measurements of scar elasticity. Two double-blinded dermatologists will be asked to rate the scars according to the objective scar scales at the 10 day/ 3 week and 3 month follow-up exams. | 10 day/3 weeks and 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Dehiscence | The rate of dehiscence observed will be noted and recorded by the treating physicians. | 10 days/3 weeks and 3 months |
| Subject Satisfaction | The subjects will fill out the VAS to evaluate their overall assessment of their scar, any associated pruritus and pain. The subjects will also fill out a Subject Satisfaction Survey to evaluate subject preference for closure. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Murad Alam, MD | Northwestern University | Principal Investigator |
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| ID | Term |
|---|---|
| D014014 | Tissue Adhesives |
| ID | Term |
|---|---|
| D001697 | Biomedical and Dental Materials |
| D020313 | Specialty Uses of Chemicals |
| D020164 | Chemical Actions and Uses |
| D053831 | Surgical Fixation Devices |
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| Tissue Adhesive (Derma-Bond) | Procedure | Approximately half of wounds will be randomized to be closed with tissue adhesive. |
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| Subcuticular polyglactin-910 combined with tissue adhesive | Procedure | Approximately half of the experimental wounds will be randomized to be closed with a combination of subcuticular polyglactin-910 and tissue adhesive. |
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| 10 days/3 weeks and 3 months |
| Adverse Events | The treating physicians will note occurrence and extent of any adverse events associated with either type of epidermal closure. | 10 days/3 weeks and 3 months |
| D013523 | Surgical Equipment |
| D004864 | Equipment and Supplies |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |