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The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of cutaneous surgery wounds with full-thickness skin grafts improves scar cosmesis compared to wound closure with sutures.
The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of cutaneous surgery wounds with full-thickness skin grafts improves scar cosmesis compared to wound closure with sutures. Our aims are to compare outcomes using a split wound model, where half of the wound is treated with 2-octylcyanoacrylate and the other half is repaired with sutures, per the standard of care. Three-months post-surgery, the scar will be measured via the physician observer scar assessment scale, a validated scar instrument. Our hypothesis is that 2-octylcyanoacrylate will result in cosmetically superior wound outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Wound closure with 2-octylcyanoacrylate | Experimental | One side of the patient's wound defect will be assigned to wound closure with 2-octylcyanoacrylate liquid bonding agent). |
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| Wound closure with 5-0 vicryl sutures | Active Comparator | One side of the patient's wound defect will be assigned to wound closure with 5-0 vicryl sutures. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wound Closure with 2-octylcyanoacrylate | Procedure |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Appearance of Scar on the Patient and Observer Scar Assessment Scale | After surgical procedure, half of the subject's wound will be with 2-octylcyanoacrylate, while the other half is closed 5-0 vicryl sutures. After 3 months, subjects will return to clinic for evaluation of the cosmesis of both types of closure techniques. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Graft Failure on Case Report | The secondary endpoint will include incidence of graft failure (partial and complete on both sides). | 3 months |
| Incidence of Complications on Case Report |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Eisen, M.D. | University of California, Davis | Principal Investigator |
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| ID | Term |
|---|---|
| C100832 | octyl 2-cyanoacrylate |
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| Wound Closure with 5-0 Vicryl Sutures |
| Procedure |
|
Noting the presence or absence of bleeding, dehiscence, infection or spitting sutures.
| 3 months |