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| Name | Class |
|---|---|
| Göteborg University | OTHER |
The main objective is to investigate gut microflora composition in relation to cardiometabolic risk markers, and to investigate the effects of 3 days intervention with a barley kernel based product on these variables.
100 subjects were invited to deliver faecal samples. From this cohort 40 subjects were chosen based on their gut microflora composition to participate in the Barley intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Barley kernel bread | Experimental |
| |
| Whit wheat flour bread | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Barley kernel bread | Other | 3 days intervention with barley kernel bread |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in glucose regulation | blood glucose concentrations are measured fasting and postprandially a standardised breakfast after interventions with barley based bread and white wheat bread, respectively | Changes in fasting and postprandial blood glucose concentrations after 3 days intervention with a barley based bread in comparison to 3 days intervention with a white wheat based bread |
| Changes in colonic microbiota composition after intervention with barley | Gut microbiota composition are characterised after interventions with barley based bread and white wheat bread, respectively | Changes in colonic microbiota composition after 3 days intervention with a barley based bread in comparison to 3 days intervention with a white wheat based bread |
| nucleotide polymorphisms (SNP in TCF7L2) | investigate nucleotide polymorphisms that associate with cardiometabolic traits, in particular the SNP in TCF7L2 | at baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson, PhD | Food for Health Science Centre, Medicon Village, Lund University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Food for Health Science Centre, Medicon Village, Lund University | Lund | , SE-223 81 LUND | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30046942 | Derived | Sandberg J, Kovatcheva-Datchary P, Bjorck I, Backhed F, Nilsson A. Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics. Eur J Nutr. 2019 Sep;58(6):2365-2376. doi: 10.1007/s00394-018-1788-9. Epub 2018 Jul 25. |
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| white wheat bread |
| Other |
3 days intervention with white wheat bread |
|