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The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine | Experimental | 20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine |
|
| 20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine | Experimental | 20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine |
|
| 20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline | Experimental | 20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| isolated whey protein | Dietary Supplement | isolated whey protein |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in myofibrillar fractional synthetic rate (FSR) | one day and 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change in non-myofibrillar fractional synthetic rate (FSR) | baseline and one day of feeding | |
| Capillary dilatation and blood flow | Determine if inactivity reduces the feeding-induced increase in capillary dilation and nutrient delivery and whether citrulline rescues this in "resistant" muscle or augments it in the "healthy" muscle as measured by Definity infusion and contrast enhanced ultrasound (CEUS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stuart Philips, PhD | McMaster University | Principal Investigator |
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| ID | Term |
|---|---|
| D005998 | Glycine |
| D002956 | Citrulline |
| ID | Term |
|---|---|
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
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| micellar whey protein | Dietary Supplement | micellar whey protein |
|
| glycine | Dietary Supplement | glycine |
|
| citrulline | Dietary Supplement | citrulline |
|
| 2 weeks |