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During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility. Protein consumption may be one opportunity to alleviate this problem especially when consumed in appropriate amounts following resistance training. This study is designed to determine if a soy dairy protein blend, shown to be effective in younger adults, will produce beneficial muscle protein synthesis in older healthy adults following resistance exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Soy Dairy Protein Blend | Experimental | 30 grams of Soy Dairy Protein Blend given as a single beverage following leg resistance exercise |
|
| Positive Control (Dairy Whey Protein) | Active Comparator | 30 grams of Dairy Whey Protein will be given as a single beverage following leg resistance exercise |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Soy Dairy Protein Blend | Dietary Supplement |
| ||
| Positive Control (Dairy Whey Protein) |
| Measure | Description | Time Frame |
|---|---|---|
| Fractional Synthetic Rate (Muscle Protein Synthesis) | The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-[ring-13C6]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment. | baseline, 3 hrs, 5 hrs |
| Measure | Description | Time Frame |
|---|---|---|
| Anti-inflammatory and Anti-oxidant Markers | Proteins will be assessed that are markers of oxidative damage and inflammation (NFkB, IL-1, IL-6) and proteolysis (MuRF, MAFBx). | baseline, 3 hrs, 5 hrs |
| Intracellular Signalling Genes and Proteins |
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Inclusion Criteria:
55-70 yr olds Stable Body weight
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Blake Rasmussen, PhD | University of Texas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Texas Medical Branch | Galveston | Texas | 77555 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27798330 | Derived | Borack MS, Reidy PT, Husaini SH, Markofski MM, Deer RR, Richison AB, Lambert BS, Cope MB, Mukherjea R, Jennings K, Volpi E, Rasmussen BB. Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men. J Nutr. 2016 Dec;146(12):2468-2475. doi: 10.3945/jn.116.231159. Epub 2016 Oct 26. |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Dietary Supplement |
|
Phosphorylation of Mammalian Target of Rapamycin (mTOR) pathway will be measured using Western blot techniques
| baseline, 3 hrs, 5 hrs |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |