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| Name | Class |
|---|---|
| University of Texas | OTHER |
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Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow). This intermediate rate may allow soy protein to have an extended window of muscle protein synthesis that has not been monitored in previous studies. While most of the sports nutrition "recovery" products are dairy-based protein blends (high in branched-chain amino acids), soy protein offers additional benefits that can make an important contribution to these types of sports nutrition products. Soy protein contains approximately 300% more arginine and 30% more glutamine compared to whey protein and these two amino acids may bring additional benefits (immunity and hydration, respectively) to athletes. A "blend" of high-quality proteins (soy and dairy) may be the optimal sports nutrition product for athletes to consume following training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Whey Protein Isolate | Active Comparator |
| |
| Protein Blend (soy, whey and casein) | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein Blend | Other | Single intake of approximately 20 grams of total protein |
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| Measure | Description | Time Frame |
|---|---|---|
| Muscle Protein Synthesis or Fractional synthesis rate (FSR) | The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-[ring-13C6]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment. | baseline, 3 hours, 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| oxidative and inflammatory markers | Proteins will be assessed that are markers of oxidative damage and inflammation (NFkB, IL-1, IL-6) and proteolysis (MuRF, MAFBx). | baseline, 3 hours, 5 hours |
| Phosphorylation of protein in muscle protein signaling pathways |
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Inclusion:
Exclusion criteria will be:
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| Name | Affiliation | Role |
|---|---|---|
| Ratna Mukherjea, PhD | Solae, LLC | Principal Investigator |
| Mark B Cope, PhD | Solae, LLC | Principal Investigator |
| Blake B Rasmussen, PhD | UTMB | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UTMB General Clinical Research Center, located in the John Sealy Hospital | Galveston | Texas | 77555 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23343671 | Derived | Reidy PT, Walker DK, Dickinson JM, Gundermann DM, Drummond MJ, Timmerman KL, Fry CS, Borack MS, Cope MB, Mukherjea R, Jennings K, Volpi E, Rasmussen BB. Protein blend ingestion following resistance exercise promotes human muscle protein synthesis. J Nutr. 2013 Apr;143(4):410-6. doi: 10.3945/jn.112.168021. Epub 2013 Jan 23. |
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Phosphorylation of mTOR, 4E-BP1, S6K1, S6, and eEF2 will be measured using Western blot techniques as previously described. |
| baseline, 3 hours, 5 hours |