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| Name | Class |
|---|---|
| National Dairy Council | OTHER |
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When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e. performing resistance exercise) and proper nutrition, in particular eating enough high quality protein, can help slow the loss of muscle mass or potentially even reverse it. Protein and resistance exercise are thought to do this by stimulating your muscle to make more proteins and/or potentially by slowing down the rate at which your body breaks proteins down. Whey protein is a high quality protein isolated from milk and is known to stimulate new protein synthesis for all proteins in your body. However, to date, the effect that whey protein has on muscle protein synthesis, particularly in the elderly has yet to be determined. Thus the purposes of this study are: 1) to determine if whey is an effective source of protein that will stimulate muscle protein synthesis in the elderly, similar to what we have previously seen in young persons; 2) to determine the smallest amount of whey protein to consume to maximally stimulate your muscle to make new proteins; 3) to see if performing resistance exercise will augment the increase in new muscle protein synthesis with whey consumption; and 4) to try and found out if whey is more effective than soy protein in stimulating new muscle protein synthesis and suppressing muscle protein breakdown in the elderly, similar to what we have previously seen in young persons
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group 0 g protein | Other | Control group in which a placebo drink containing no protein is given following unilateral knee extension exercise |
|
| 10g whey | Experimental | 10g whey protein given following unilateral knee extension exercise |
|
| 20g whey | Experimental | 20g whey protein given following unilateral knee extension exercise |
|
| 30g whey | Experimental | 30g whey protein given following unilateral knee extension exercise |
|
| 40g whey | Experimental | 40g whey protein given following unilateral knee extension exercise |
|
| 20g soy | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whey or soy protein | Dietary Supplement | Whey and casein are isolated milk proteins |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle protein synthesis | Acute within the day | |
| whole body amino acid oxidation | acute within the day |
| Measure | Description | Time Frame |
|---|---|---|
| muscle protein breakdown | Acute within the day | |
| serum insulin | acute within the day | |
| plasma amino acid concentrations |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stuart Phillips, Ph.D. | McMaster University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| McMaster University | Hamilton | Ontario | L8S 4K1 | Canada |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000067796 | Whey |
| D030262 | Soybean Proteins |
| ID | Term |
|---|---|
| D008892 | Milk |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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20g soy protein given following unilateral knee extension exercise
|
| 40g soy | Experimental | 40g soy protein given following unilateral knee extension exercise |
|
| acute within the day |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D003611 |
| Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |
| D010940 | Plant Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D014674 | Plant Proteins, Dietary |
| D004044 | Dietary Proteins |
| D045730 | Soy Foods |
| D000067075 | Vegetable Products |
| D014675 | Vegetables |