Daily Protein Intake Distribution and MPS (ARCIII)

Effect of Balanced Daily Protein Distribution Supplemented With Whey Protein on Muscle Protein Synthesis in Overweight Older Men During Calorie Restriction and Exercise (ARC III)

To determine whether a balanced total daily dietary protein distribution supplemented with whey protein during a weight-loss intervention will result in increased muscle protein synthesis

Inclusion Criteria:

• Overweight/obese (BMI 27-40 kg/m2)
• Non-smokers
• Non-diabetic
• No history of hyperlipidemia
• Not taking medications thought to interfere with study
• Considered generally healthy

Exclusion Criteria:

• Efforts to lose weight in previous 16 weeks
• Hyperlipidemia
• Blood pressure ≥ 140/90 mmHg
• Smoking
• Heart and other organ disease
• Type 2 diabetes
• Gastrointestinal disease
• Orthopedic injury interfering with exercise
• Use of certain medications (HRT, antihypertensives, diuretics, antiarythmia medications, antiresorptive agents, anabolic agents, hypoglycemic agents, and statins known to affect muscle i.e. Simvastatin and Zocor)