Protein Supply in Elderly

Overnight Protein Supply as a Dietary Strategy to Improve Muscle Mass in Elderly.

Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase mitochondrial mass, and/or improve muscle tissue repair. The goal of this proposal will be to provide further insight into the responsiveness of the muscle protein synthetic machinery to food intake in relation to age.

Inclusion Criteria:

• Males
• Age between 65 and 80 years
• BMI < 30 kg/m2

Exclusion Criteria:

• Type 2 diabetic patients
• Use of medication
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. artrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis).
• Use of anticoagulants, blood diseases, allergy for lidocain.
• Contra indications for the use of a nasogastric tube: high risk of aspiration, gastric stasis, gastro-oesophageal reflux, upper gastrointestinal stricture, nasal injuries and base of skull fractures.
• Patients suffering from PKU (Phenylketonuria).