Effects of Ginger on Nonalcoholic Fatty Liver Disease in T2DM

The Effects of Ginger on Biochemical Markers and Imaging Studies of Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease (NAFLD)

The investigators want to evaluate the effects and safety of ginger in treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).

Ginger (Zingiber officinale Roscoe) has been cultivated for medicinal and culinary purposes for at least two millennia. It contains several hundred valuable compounds and new constituents are still being found. Ginger's high antioxidant value has proved highly effective with its ability to scavenge a number of free radicals and protect cell membrane lipids from oxidation in a dose-dependent manner.

In a randomized double-blind placebo-controlled clinical trial, the investigators want to investigate the effects of ginger in treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).

Inclusion Criteria:

• Controlled type 2 diabetes mellitus (HbA1c<7%)
• Age: 20-65 years
• Body mass index: 18-35 kg/m2
• Serum ALT level: >60 U/Lit. in males, >38 U/Lit. in females
• Grade >=2 fatty liver in liver sonography

Exclusion Criteria:

• Pregnancy
• Acute or chronic liver failure
• Acute or chronic renal failure
• Autoimmune or viral hepatitis
• Wilson's disease
• Alcoholism
• Malignancy
• Hypothyroidism or hyperthyroidism
• Drug used in last three months: OCP, vitamin E, ursodeoxycholic acid, glucocorticoids.