Effects of Ginger Supplementation on NF-KB in Peripheral Blood Mononuclear Cells in Type 2 Diabetes Mellitus

Effects of Oral Ginger Supplementation on NF-KB (Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells) in Peripheral Blood Mononuclear Cells (PBMC) and Glycemic and Lipid Profiles in Patients With Type 2 Diabetes Mellitus

This study evaluates the effect of ginger on NF-KB level in Peripheral Blood Mononuclear Cells in type 2 diabetic patients. Half of patients will receive ginger, while the other half will receive placebo.

ginger is a plant with lots of phytochemicals which have antioxidant effects. It reduces the NF-KB levels in the cells because of its antioxidant effects. It can reduces insulin resistance as a result of NF-KB reduction in diabetes.

Inclusion Criteria:

• type 2 of diabetes diagnosed for 1 to 10 years
• age 30-60 years
• BMI = 18.5-35 kg/m*m
• treatment with Metformin or Glibenclamide

Exclusion Criteria:

• Treatment with insulin
• Weight loss more than 10% in 6 months
• Treatment with TZDs (thiazolidinediones)
• Pregnancy and breast feeding
• Smoking and alcohol consumption
• Multivitamin-mineral and polyphenols and omega-3 and 6 supplementation in the last 3 months and during study
• Ginger supplementation and herbal medicines
• Anticoagulation consumption such as heparin and warfarin
• NSAIDs such as diclofenac and salicylate drugs such as aspirin, corticosteroids such as prednisone consumption during 1 month ago and during the study
• Infectious and inflammatory diseases such as rheumatoid arthritis
• Impaired hepatic, renal and gastrointestinal function
• Cancer
• Currently suffering from acute illness that needs medical treatment