Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study evaluates the effect of ginger on NF-KB level in Peripheral Blood Mononuclear Cells in type 2 diabetic patients. Half of patients will receive ginger, while the other half will receive placebo.
ginger is a plant with lots of phytochemicals which have antioxidant effects. It reduces the NF-KB levels in the cells because of its antioxidant effects. It can reduces insulin resistance as a result of NF-KB reduction in diabetes.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ginger | Experimental | Ginger (Zingiber officinale Roscoe) 500 mg capsules (2000 mg per day) by mouth twice daily (BID) for 10 weeks |
|
| Placebo | Placebo Comparator | Placebo matching with ginger 0 mg capsules by mouth twice daily (BID) for 10 weeks Placebo twice daily |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ginger | Dietary Supplement | Ginger 500 mg capsules (2000 mg per day) by mouth twice daily (BID) for 10 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in NF-KB at 10 weeks | Baseline and 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in FBS (mg/dl) at 10 weeks | FBS (Fasting Blood sugar) (mg/dl) | Baseline and 10 weeks |
| Change from Baseline in HDL-C (mg/dl) at 10 weeks | HDL-C (High Density Lipoprotein) (mg/dl) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Ahmad Saedisomeolia, Prof.assoc | Tehran University of Medical Sciences | Study Director |
| Motahare Makhdoomiarzati, Msc student | Tehran University of Medical Sciences | Principal Investigator |
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19233241 | Result | Jung HW, Yoon CH, Park KM, Han HS, Park YK. Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway. Food Chem Toxicol. 2009 Jun;47(6):1190-7. doi: 10.1016/j.fct.2009.02.012. Epub 2009 Feb 20. | |
| 17950516 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| C000713927 | ginger extract |
| D005433 | Flour |
| ID | Term |
|---|---|
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| placebo | Dietary Supplement | Placebo matching with ginger 0 mg capsules by mouth twice daily (BID) for 10 weeks |
|
|
| Baseline and 10 weeks |
| Change from Baseline in LDL-C (mg/dl) at 10 weeks | LDL-C (Low Density Lipoprotein) (mg/dl) | Baseline and 10 weeks |
| Change from Baseline in Total-C (mg/dl) at 10 weeks | Total-C (Total Cholesterol) (mg/dl) | Baseline and 10 weeks |
| Change from Baseline in TG (mg/dl) at 10 weeks | TG (Triacylglycerol) (mg/dl) | Baseline and 10 weeks |
| Change from Baseline in Hb A1C at 10 weeks | Hb A1C (Glycated hemoglobin) | Baseline and 10 weeks |
| Change from Baseline in insulin (µlU/ml) at 10 weeks | Baseline and 10 weeks |
| Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol. 2008 Feb;46(2):409-20. doi: 10.1016/j.fct.2007.09.085. Epub 2007 Sep 18. |
| 23843863 | Result | Li XH, McGrath KC, Tran VH, Li YM, Duke CC, Roufogalis BD, Heather AK. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells. Evid Based Complement Alternat Med. 2013;2013:146142. doi: 10.1155/2013/146142. Epub 2013 Jun 16. |
| 3448918 | Result | Ogawa Y, Yamaguchi K, Tanaka T, Morozumi M, Kitagawa R. [Evaluation of the enzymatic method using oxalate oxidase for urinary oxalate assay]. Hinyokika Kiyo. 1987 Dec;33(12):1951-4. Japanese. |
| D004700 | Endocrine System Diseases |