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Single macronutrients will be consumed before sleep by obese men. Overnight lipolysis will be measured with the microdialysis technique by measuring glycerol concentration and blood flow in abdominal adipose tissue. Morning fat oxidation will be measured with indirect calorimetry.
The investigators hypothesize that carbohydrate intake will blunt the overnight lipolysis rate compared to casein protein and a non-caloric placebo. The investigators also hypothesize that casein and placebo will not be significantly different from each other in terms of overnight lipolysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Casein Protein | Experimental | Casein protein (30g) will be consumed as the last food/caloric beverage and within 30 minute of sleep |
|
| Non-caloric Placebo | Placebo Comparator | The non-caloric placebo beverage will will be consumed as the last food/caloric beverage and within 30 minute of sleep |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Casein Protein | Other | The effect of casein protein consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lipolysis | Measuring lipolysis using the microdialysis technique. Samples will be collected at various time intervals Vial 1: 30 minute; 2.0 uL/min flow rate Vial 2: 4 hours; 0.3 uL/min flow rate Vial 3: Overnight; 0.3 uL/min flow rate (before taking nighttime supplement) Vial 4: Morning sample #1; 2.0 uL/min flow rate (upon waking) Vial 5: Morning sample #2; 2.0 uL/min flow rate (arrive to lab) Blood flow will be measured using the Ethanol technique | Change from day 1 to day 2 to day 3 of testing |
| Measure | Description | Time Frame |
|---|---|---|
| Resting Metabolic Rate (RMR) | RMR will be measured with indirect calorimetry using the ventilated hood technique | Change from day 1 to day 2 to day 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite | Appetite will be measured by visual analog scales | Change from Baseline to day 1, 2, and 3 |
| Blood hormones | Hormones related to appetite and metabolism will be examined. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael J Ormsbee, PhD | Florida State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Sports Science and Medicine, Florida State University | Tallahassee | Florida | 32306 | United States |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Non-caloric placebo | Other | The effect of a non-caloric placebo consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined |
|
| Change from Baseline to day 1, 2, and 3 |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |