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The investigators predict that giving patients paracetamol in the operative period will reduce their need for opioid pain reducers in the post operative setting.
This study is designed as a population-based prospective, double blind cohort study. A prospective cohort of patients admitted to laparoscopic gastric banding due to morbid obesity
STUDY GOALS
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Paracetamol | Active Comparator |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Paracetamol | Drug |
|
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| amount of morphine | The primary outcome will be the comparison amount of morphine injected in each group until discharge | Until discharge (participants will be followed for the duration of hospital stay, an expected average of 3 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Complication during treatment of patient in PACU: | Complication during treatment of patient in PACU, including:
|
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Soroka Medical Center, Ben Gurion University of the Negev | Beersheba | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36161276 | Derived | Semyonov M, Bartulovic A, Cohen N, Berzon B, Fedorina E, Lerman S, Semionov A, Friger M, Acker A, Geftler A, Zlotnik A, Brotfain E. The effect of timing of intravenous paracetamol on perioperative pain and cytokine levels following laparoscopic bariatric surgery, a randomized controlled trial. Obesity (Silver Spring). 2022 Nov;30(11):2185-2193. doi: 10.1002/oby.23545. Epub 2022 Sep 25. |
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| Drug |
|
| Until discarge from PACU (participants will be followed for the duration of PACU stay, an expected average of 2 hours) |
| Time discharging from PACU | Until discharge from PACU (participants will be followed for the duration of PACU stay, an expected average of 2 hours) |
| Length of hospitalization | Until discharge from hospital (participants will be followed for the duration of hospital stay, an expected average of 3 days) |
| Complications during hospitalization. | Complications during hospitalization, including :
| Until discharge from hospital (participants will be followed for the duration of hospital stay, an expected average of 3 days) |
| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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