The Effect of Timing of Intravenous Paracetamol Administration on Post-surgical Pain

The Effect of Timing of Intravenous Paracetamol Administration on Post-surgical Pain and Cytokines Levels Following Laparoscopic Sleeve Gastrectomy

This study is designed as a population-based prospective randomized cohort study. A prospective cohort of patients admitted to laparoscopic sleeve gastrectomy due to morbid obesity

All adult consecutive patients admitted to surgical departments for laparoscopic sleeve gastrectomy will be enrolled prospectively.

For the purposes of the current study we want to determine how much paracetamol (acetaminophen) can reduce the cytokines levels in these patients

The study enrollment period is planned to be a year. The follow-up period for each patient will be until discharge from the hospital.

Inclusion Criteria:

• Age ≥18 years
• Patients admitted for laparoscopic sleeve gastrectomy
• Elective surgery
• BMI > 40
• American Society of Anesthesiology Classification: 1-2

Exclusion Criteria:

• Patients' refusal to participate in the study
• Patients unable to give an informed consent
• Pregnancy
• Emergency surgery
• Patient with known allergy to paracetamol
• Patient with hepatic failure
• international normalized ratio >1.7
• Albumin<3.5g/Dl
• Bilirubin >2mg/dL
• Patient with fever > 37.5 ° C
• Patient with hemoglobin < 8
• Patients chronically treated with steroids or steroid-treated patients over a month in the year preceding surgery.

Drug addict