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We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Total intravenous anesthesia group | Experimental | This group received propofol and remifentanil for the maintenance of general anesthesia. |
|
| Inhalation anesthesia group | Experimental | This group received sevoflurane for the maintenance of general anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol, remifentanil | Drug |
| ||
| Sevoflurane |
| Measure | Description | Time Frame |
|---|---|---|
| Clotting time of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia | |
| Clot firmness time of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia | |
| Alpha angle of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia | |
| Maximum clot firmness of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Hemoglobin | 10 minutes before the induction of anesthesia | |
| Hematocrit | 10 minutes before the induction of anesthesia | |
| Platelet count |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
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| ID | Term |
|---|---|
| D002386 | Cataract |
| D012163 | Retinal Detachment |
| D011625 | Pterygium |
| D007634 | Keratitis |
| D014823 | Vitreous Hemorrhage |
| ID | Term |
|---|---|
| D007905 | Lens Diseases |
| D005128 | Eye Diseases |
| D012164 | Retinal Diseases |
| D003229 | Conjunctival Diseases |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D000077208 | Remifentanil |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Drug |
|
| 10 minutes before the induction of anesthesia |
| International normalized ratio of prothrombin time | 10 minutes before the induction of anesthesia |
| Activated partial thromboplastin time | 10 minutes before the induction of anesthesia |
| Fibrinogen | 10 minutes before the induction of anesthesia |
| D003316 |
| Corneal Diseases |
| D005130 | Eye Hemorrhage |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |