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Comparison of the diagnostic capabilities of rotational thromboelastometry (ROTEM) and standard coagulogram in the detection of disorder and correction of the hemostasis system in the perioperative period in patients who underwent surgical intervention on the aorta under cardiopulmonary bypass and or circulatory arrest.
The patient is monitored in the intensive care unit according to the following scheme: ROTEM (NATEM, INTEM, EXTEM, FIBTEM; with high clotting time (CT) values in INTEM - HEPTEM is done) and a coagulogram (activated coagulation time (ACT), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen, antithrombin III, platelet aggregation) are done on admission and after 6 hours - with a smooth course of the perioperative period. If it is necessary or the development of disorders in the form of bleeding or thrombosis that require correction, ROTEM and a coagulogram are done, treatment is carried out, and after elimination of the causes, ROTEM and a coagulogram are examined in dynamics to assess the effectiveness of the therapy.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ROTEM and standard coagulation tests | Device | ROTEM and standard coagulation tests assessment |
| Measure | Description | Time Frame |
|---|---|---|
| The coagulation index | Сhanges of the coagulation index | an average of during the first day after surgery |
| Activated coagulation time | Сhanges of the activated coagulation time | an average of during the first day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of repeated operations | Percentage of repeated operations | an average of 24 hours after surgery |
| Percentage of multiple organ failure | Percentage of multiple organ failure |
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Inclusion Criteria:
Exclusion Criteria:
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Patients after surgical interventions on the aorta with cardiopulmonary bypass and/or circulatory arrest.
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| Name | Affiliation | Role |
|---|---|---|
| Aleksandr Eremenko, MD | Petrovsky National Research Centre of Surgery | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Petrovsky National Research Centre of Surgery | Moscow | 119991 | Russia |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 27, 2025 | |
| Reset | Aug 11, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 27, 2025 | Aug 11, 2025 |
| ID | Term |
|---|---|
| D020141 | Hemostatic Disorders |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006474 | Hemorrhagic Disorders |
| D006402 | Hematologic Diseases |
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| an average of 24 hours after surgery |
| Percentage of serious infectious complication | Percentage of serious infectious complication | an average of 24 hours after surgery |
| D006425 |
| Hemic and Lymphatic Diseases |