Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University Hospital, Essen | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of the study is to determine the efficacy of two different algorithms for coagulation management in patients undergoing cardiac surgery suffering from increased bleeding tendency. Algorithm 1 is based on conventional coagulation analyses (INR, aPTT, platelet count, fibrinogen concentration,...) and Algorithm 2 is based on thrombelastometry using the ROTEM-device and impedance aggregometry using the Multiplate device.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| POC algorithm | Active Comparator | cardiac surgery patients suffering from increased perioperative bleeding and being treated following Point of Care based algorithm |
|
| conventional algorithm | Active Comparator | cardiac surgery patients suffering from increased perioperative bleeding and being treated following conventional coagulation management algorithm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Point-of-Care versus conventional coagulation management | Procedure | Patients are randomized to receive either point-of-care based or conventional coagulation measurements based coagulation therapy in the case of increased perioperative bleeding tendency |
| Measure | Description | Time Frame |
|---|---|---|
| amount of transfused red blood cell concentrates | 24 h after begin of surgical intervention |
| Measure | Description | Time Frame |
|---|---|---|
| other transfused blood products including FFP, platelet concentrates and coagulation factor concentrates | 24h after surgical intervention | |
| rate of rethoracotomy for bleeding | 24h after surgical intervention |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Christian F Weber, Dr. | Johann Wolfgang Goethe University Frankfurt, Clinic for Anaesthesiology, Intensive Care Medicine and Pain Therapy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Essen, Clinic for Anesthesiology and Intensive Care Medicine | Essen | 45473 | Germany | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Görlinger K, Jambor C, Hanke A, Adamzik M, Hartmann M, Rahe-Meyer N. Thrombelastometry and impedance aggregometry based algorithm for coagulation management in cardiac surgery. Intensive Care Med 33: 196, 2007. | ||
| Background | Görlinger K, Jambor C, Hanke A, Adamzik M, Hartmann M, Rahe-Meyer N. Perioperative coagulation management and controll of platelet transfusion by point-of-care platelet function analysis. Transfus Med Hemother 34: 396-411, 2007. | ||
| Background | Görlinger K, Bergmann L, Hartmann M, Marggraf G, Kamler M, Müller-Beißenhirtz H. Reduction of blood transfusion rate by thrombelastometry and impedance aggregometry based point-of-care coagulation management in thoracic and cardiovascular surgery. Appl Cardiopulmon Pathophysiol 13: 174-7, 2009. | ||
| 22914710 | Derived |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020141 | Hemostatic Disorders |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006474 | Hemorrhagic Disorders |
| D006402 | Hematologic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D019095 | Point-of-Care Systems |
| ID | Term |
|---|---|
| D006751 | Hospital Information Systems |
| D006739 | Hospital Administration |
| D058016 | Health Facility Administration |
| D009934 | Organization and Administration |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| ventilation time on ICU | till discharge from ICU |
| Johann Wolfgang Goethe University Frankfurt, Clinic for Anaesthesiology |
| Frankfurt am Main |
| 60590 |
| Germany |
| Weber CF, Gorlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, Cohn LH, Zacharowski K. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012 Sep;117(3):531-47. doi: 10.1097/ALN.0b013e318264c644. |
| D006425 |
| Hemic and Lymphatic Diseases |
| D006298 | Health Services Administration |
| D008331 | Management Information Systems |
| D010346 | Patient Care Management |