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| Name | Class |
|---|---|
| Glostrup University Hospital, Copenhagen | OTHER |
| Rigshospitalet, Denmark | OTHER |
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The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Premenopausal women | Experimental | The Premenopausal women are randomized to exercise by spinning (cycle) |
|
| Postmenopausal women | Experimental | The Postmenopausal women are randomized to exercise by spinning (cycle) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spinning | Behavioral | After the baseline studies the pre and postmenopausal women will be randomized to spinning training groups and the intervention will last for 3 months. The spinning group will spin three times per week under guidance of a trained instructor. The training is heart rate monitored. |
| Measure | Description | Time Frame |
|---|---|---|
| Leg vascular function | Measurements of leg blood flow by ultrasound doppler during exercise and during femoral arterial infusion of vasodilators | Baseline comparison and changes from baseline to 3 months |
| Cardiac structure and function | Magnetic resonance imaging and transthoracic echocardiography | Baseline comparison and changes from baseline to 3 months |
| Platelet function | Platelet aggregation assay of whole blood and platelet rich plasma | Baseline comparison and changes from baseline to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Expression of proteins in muscle samples | Western Blot analysis of proteins of relevance for vascular function and metabolism | Baseline comparison and changes from baseline to 3 months |
| Maximal aerobic effect |
| Measure | Description | Time Frame |
|---|---|---|
| Anthropometry | Dual x-ray absorptiometry, height, weight, waist and hip circumference | Baseline comparison and changes from baseline to 3 months |
| Activity measure | Activity measure for one week by accelerometer |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Erik Richter, MD PhD | University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Copenhagen | Copenhagen | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28862950 | Derived | Egelund J, Jorgensen PG, Mandrup CM, Fritz-Hansen T, Stallknecht B, Bangsbo J, Nyberg M, Hellsten Y. Cardiac Adaptations to High-Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study. J Am Heart Assoc. 2017 Aug 18;6(8):e005469. doi: 10.1161/JAHA.117.005469. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D001791 | Blood Platelet Disorders |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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|
Maximal oxygen uptake during an incremental cycle ergometry test with gas analysis
| Baseline comparison and changes from baseline to 3 months |
| Genomic profile in blood samples | Genomic analysis of parameters for vascular and metabolic health | Baseline comparison and changes from baseline to 3 months |
| Insulin sensitivity and glycaemic control | Fasting plasma glucose analysis and oral glucose tolerance test | Baseline comparison and changes from baseline to 3 months |
| Arterial blood pressure | Baseline comparison and changes from baseline to 3 months |
| Gene expression of proteins in muscle samples | Gene analysis of relevance for vascular and metabolic function | Baseline comparison and changes from baseline to 3 months |
| Health related parameters in blood | Plasma lipid status and other variables related to vascular health | Baseline comparison and changes from baseline to 3 months |
| Baseline comparison and changes from baseline to 3 months |