Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase

A Training Intervention Study in Late Pre- and Early Postmenopausal Women Investigating the Changes in Adipose Tissue Metabolism and Peripheral Insulin Sensitivity

The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.

Inclusion Criteria:

• Premenopausal OR Postmenopausal (45-57 years)
• No chronical Diseases
• BMI > 18,5 and < 30
• Sedentary (no regular physical activity the last 2 years)
• Either regular bleeding (premenopausal) OR no menstruation for at least 2 years (postmenopausal)
• Plasma measurements:

Premenopausal: estradiol > 0.20nmol/l, Follicle Stimulating Hormone < 22 IU/l and progesterone > 2.5 nmol/l Postmenopausal: estradiol < 0.20nmol/l, Follicle Stimulating Hormone > 22 IU/l and progesterone from 0.3-2.5 nmol/l

Exclusion Criteria:

• Smoking
• Excessive alcohol intake
• Regular medication including hormone replacement treatment