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| Name | Class |
|---|---|
| Rigshospitalet, Denmark | OTHER |
| Glostrup University Hospital, Copenhagen | OTHER |
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The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Premenopausal women | Active Comparator | The premenopausal women will be attending Spinning classes. |
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| Postmenopausal Women | Experimental | The postmenopausal women will be attending Spinning classes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spinning | Behavioral | After the baseline studies, the women will perform Spinning three times a week. Two of the sessions are performed on our location by trained instructors and the third training is self-training in a local fitness center where we provide free membership. All trainings are heart rate monitored. |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin stimulated uptake of glucose in adipose tissue | Measured by Positron Emission Tomography-Computed tomography (PET/CT) | Baseline and 3 months |
| Hyperinsulinemic euglycemic clamp | Glucose metabolized (mg/kg/min) | Baseline and 3 months |
| Adipose tissue distribution | Accessed by Magnetic Resonance Imaging (MRI). | Baseline and 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Central insulin sensitivity | Fasting plasma insulin, homeostasis model assessment insulin resistance and measures of central insulin sensitivity derived from an oral glucose tolerance test | Baseline and 3 months |
| Maximal oxygen uptake (ml/O2/kg/min) |
| Measure | Description | Time Frame |
|---|---|---|
| Dietary registration | Daily food intake for three week days and one week-end day will be reported by the subjects | Baseline and 3 months |
Inclusion Criteria:
Premenopausal: estradiol > 0.20nmol/l, Follicle Stimulating Hormone < 22 IU/l and progesterone > 2.5 nmol/l Postmenopausal: estradiol < 0.20nmol/l, Follicle Stimulating Hormone > 22 IU/l and progesterone from 0.3-2.5 nmol/l
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ylva Hellsten, Proff. | University of Copenhagen | Principal Investigator |
| Bente M Stallknecht, Proff. MD | University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department og Biomedical Sciences | Copenhagen N | 2200 | Denmark |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| C564221 | Glucocorticoid Receptor Deficiency |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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|
Measured using indirect calorimetry and an incremental bicycle protocol
| Baseline and 3 months |
| Metabolic syndrome | As measured by high density lipoprotein, triglycerides, waist circumference, blood pressure, mean arterial pressure, fasting glucose and composite metabolic syndrome scores | Baseline and 3 months |
| Health related quality of life | Measured using questionaries, semi-structured interviews and observations | Baseline and 3 months |
| Anthropometry | Measured using dual x-ray absorptiometry, height, weight, waist and hip circumference, sagittal abdominal height | Baseline and 3 months |
| Skeletal muscle biopsy | Biochemical, proteomics, metabolomics, genomics and morphological analyses | Baseline and 3 months |
| Abdominal subcutaneous adipose tissue biopsy | Biochemical, proteomics, metabolomics, genomics and morphological analyses | Baseline and 3 months |
| Resting metabolic rate | Will be measured by indirect calorimetry | Baseline and 3 months |
| Physical activity level and duration of sleep | Daily activity and duration of sleep will be recorded during one week using Actibelt® and self reporting | Baseline and 3 months |
| Microdialysis | Adipose tissue microdialysis | Baseline and 3 months |
| Femoral subcutaneous adipose tissue biopsy | Biochemical, proteomics, metabolomics, genomics and morphological analyses | Baseline and 3 months |