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Hypertensive patients with chronic periodontitis will be randomized to either intensive treatment or supragingival hygienic treatment and the effects on blood pressure will be identified.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hygenization Treatment | Placebo Comparator | Basic oral hygiene instructions Supragingival plaque removal |
|
| Intensive Treatment | Experimental | One-Stage Full-Mouth Disinfection. Scaling and root planing, four quadrants in one session. Extraction of radix relicta. Subgingival chlorhexidine (PerioKIN) (0.2%) in all pockets. Oral hygiene instructions. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intensive Treatment | Procedure | Intensive Surgical Treatment of Periodontitis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood Pressure Change | Ambulatory Blood Pressure Monitoring | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Flow Mediated Dilatation | Vascular Function Measurement | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Leukocyte Immunophenotype and Cytokine measurement | 3 months | |
| Periodontal Health Score - Probing Depth | 3 months | |
| Periodontal Health Score - CAL - Clinical Attachment Loss |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marta Czesnikiewicz-Guzik, MD PhD | Contact | 66683950 | maczesni@yahoo.co.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| J. Dietl Hospital, Department of Internal and Agricultural Medicine, Jagiellonian University | Active, not recruiting | Krakow | 31-121 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31504461 | Derived | Czesnikiewicz-Guzik M, Osmenda G, Siedlinski M, Nosalski R, Pelka P, Nowakowski D, Wilk G, Mikolajczyk TP, Schramm-Luc A, Furtak A, Matusik P, Koziol J, Drozdz M, Munoz-Aguilera E, Tomaszewski M, Evangelou E, Caulfield M, Grodzicki T, D'Aiuto F, Guzik TJ. Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. Eur Heart J. 2019 Nov 1;40(42):3459-3470. doi: 10.1093/eurheartj/ehz646. |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D002710 | Chlorhexidine |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
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| Dental Hygienization Treatment | Procedure |
|
| Chlorhexidine (Intensive Treatment) | Drug | Chlorhexidine (PerioKIN) (0.2%) implantation in dental pockets |
|
| 3 months |
| The Community Periodontal Index of Treatment Needs Index | 3 months |
| Gingival Index | 3 months |
| Jagiellonian University Dental Clinic | Recruiting | Krakow | Poland |
|
| D002318 |
| Cardiovascular Diseases |