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The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following non surgical periodontal treatment in patients affected by periodontitis and high blood pressure.
Periodontal treatment, consisting in both supra- and sub-gingival mechanical instrumentation of the root surface (scaling and root planing), will be performed by a single periodontist on patients with periodontitis and hypertension.
The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following non surgical periodontal treatment in patients affected by periodontitis and high blood pressure.
Treatment will be provided using both hand and ultrasonic instrumentation with fine tips.
FM-SRP patients will received treatment within 24 h. Q-SRP patients will received four quadrants sessions of periodontal treatment with an interval of 1 week between sessions.
Vital, endothelial function and blood inflammatory parameters will be evaluated at baseline, 24 hours after the first treatment and after 3 months. Periodontal parameters will be evaluated at baseline and after 3 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Full mouth scaling and root planing | Experimental | FM-SRP No surgical periodontal treatment will be performed in all dentition within 24 hours |
|
| Quadrant Scaling and Root Planing | Active Comparator | Q-SRP No surgical periodontal treatment will be performed in all dentition subdivided in four appointments. Each appointment will be performed in one week interval. In each appointment only a "quadrant" of the dentition will be instrumented. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FM-SRP | Procedure | Supra- and sub-gingival mechanical instrumentation of the root surface of the whole dentition within 24 hours. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Levels C-Reactive Protein | Changes in C reactive protein (CRP). Unit of measure: mg/L | Baseline, 24 hours and 3 months after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Full Mouth Plaque Score (FMPS) | Changes in FMPS. Unit of Measure: % | Baseline and 3 months after treatment |
| Full Mouth Bleeding Score (FMBS) | Changes in FMBS. Unit of Measure: % |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Filippo Graziani, DDS, PhD | University of Pisa | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Pisa | Pisa | 56121 | Italy |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D016745 | Root Planing |
| ID | Term |
|---|---|
| D012534 | Dental Scaling |
| D003777 | Dental Prophylaxis |
| D010517 | Periodontics |
| D003813 | Dentistry |
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|
| Q-SRP | Procedure | Supra- and sub-gingival mechanical instrumentation of the root surface will be performed in all dentition subdivided in four appointments. Each appointment will be performed in one week interval. In each appointment only a "quadrant" of the dentition will be instrumented.Performed in 3 weeks time frame. |
|
|
| Baseline and 3 months after treatment |
| Pocket probing depth (PPD) | Changes in PPD. Unit of Measure: mm | Baseline and 3 months after treatment |
| Clinical attachment level (CAL) | Changes in CAL. Unit of Measure: mm | Baseline and 3 months after treatment |
| Recession of the gingival margin (REC) | Changes in REC. Unit of Measure: mm | Baseline and 3 months after treatment |
| Triglycerides | Changes in triglycerides. Unit of measure: mmol/L | Baseline, 24 hours and 3 months after treatment |
| Low-density lipoprotein (LDL) | Changes in LDL. Unit of measure: mmol/L | Baseline, 24 hours and 3 months after treatment |
| High-density lipoprotein (HDL) | Changes in HDL. Unit of measure: mmol/L | Baseline, 24 hours and 3 months after treatment |
| Cholesterol | Changes in total cholesterol. Unit of measure: mmol/L | Baseline, 24 hours and 3 months after treatment |
| Glycaemia | Changes in blood glucose level; Unit of measure: mg/dL | Baseline, 24 hours and 3 months after treatment |
| Glycated Hemoglobin | Changes in Glycated Hemoglobin level; Unit of measure: mmol/mol | Baseline and 3 months after treatment |
| Insulin | Changes in Insulin level; Unit of measure: μU/mL | Baseline, 24 hours and 3 months after treatment |
| Systolic Blood Pressure (SBP) | Changes in SBP; Unit of measure: mmHg | Baseline, 24 hours and 3 months after treatment |
| Diastolic Blood Pressure (DBP) | Changes in DBP; Unit of measure: mmHg | Baseline, 24 hours and 3 months after treatment |
| Endothelial Function | Measures of endothelial function taken through Flow-Mediated dilation. Unit of Measure: % | Baseline, 24 hours and 3 months after treatment |
| D002318 |
| Cardiovascular Diseases |
| D013357 |
| Subgingival Curettage |
| D011313 | Preventive Dentistry |