Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty

Efficacy of Preoperative Intravenous Dexamethasone in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial

To determine efficacy of preoperative IV dexamethasone for postoperative pain control after TKA.

Preoperative intravenous over 0.1 mg/kg of dexamethasone could be reduced pain after primary TKA.

Inclusion Criteria:

• Osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
• 50-85 years old
• ASA class 1-3

Exclusion Criteria:

• Unable to perform spinal anaesthesia
• History of drug allergies: steroids
• Renal impairment (CrCl <30 mL/min)
• Liver impairment
• Cognitive function disorders
• Poor controlled DM (HA1C > 7.5)
• Morning DTX at operative day > 180 mg%
• Received corticosteroids within 3 months before surgery