Effect of Preoperative Intravenous Dexamethasone on Postoperative Pain After Primary Total Hip Arthroplasty

Effect of Preoperative Intravenous Dexamethasone on Postoperative Pain After Primary Total Hip Arthroplasty : A Prospective, Double-blind, Randomized Controlled Trial

To compare the effects of preoperative intravenous Dexamethasone between 10 mg and 40 mg with placebo on Postoperative Pain After Primary Total Hip Arthroplasty

It still unclear whether the effective dose preoperative intravenous dexamethasone on postoperative pain after Total Hip Arthroplasty. The research hypothesis is that the effect of 10 mg intravenous Dexamethasone in postoperative pain(5 metre walking at 24 hour) is not inferior to 40 mg intravenous Dexamethasone

Inclusion Criteria:

• Age > 18 years
• Undergoing Elective, Primary, unilateral Total Hip arthroplasty
• American Society of Anesthesiology (ASA) physical class 1-3
• BMI < 40 kg/m2

Exclusion Criteria:

• History of previous musculoskeletal injury on the same hip
• History of prior surgery on the same unilateral hip
• History of adverse effects from medication utilized in this study
• Contraindication to spinal anesthesia
• History of psychiatric disorders or cognitive impairment
• Contraindication to Corticosteroid
• Poorly controlled Diabetes mellitus
• History of ischemic heart disease or peripheral arterial disease or cerebrovascular disease
• Hepatic insufficiency (Child-Pugh score > 5)
• Renal insufficiency (Creatinine clearance < 30 mL/min)
• History of cataract or glaucoma or ocular hypertension