The Effect of General Anesthesia Immunosuppressive on Hepatitis B Virus Replication

The Effect of General Anesthesia Immunosuppressive on Hepatitis B Virus Replication

The purpose of this study is to determine whether the general anesthesia immunosuppressive could effect hepatitis B Virus replication

The change of immune state can influence HBV replication or elimination, it has been reported that a certain degree of immunosuppression occured after general anesthesia. In this study we detect the cytotoxic T lymphocyte(CTL) count and activity, interferon-γ(IFN-γ) and HBV-DNA content form the HBV patient who will accept general anesthesia. Our purpose is to evaluate the influence of general anesthesia immunosuppressive on HBV replication. If the results show that HBV-DNA quantity increases, so the patients might be given anti-HBV drugs or immune enhancer; otherwise it is indicated the general anesthesia immunosuppressive don't influence HBV replication.

Inclusion Criteria:

1. American Society of Anesthesiologists（ASA） Ⅰ - Ⅱ;
2. ability to compliance the research plan;
3. volunteered and signed for the study ;
4. HBsAg positive, no serious system disease (heart: New York Heart Association（NYHA） class Ⅰ - Ⅱ, lung: vital capacity（VC）% or maximal voluntary ventilation（MVV）%>71, forced expiratory volume at one second（FEV1.0）%>61, arterial oxygen saturation（SaO2）%>94, arterial partial pressure of oxygen（PaO2）>75 mmHg, arterial carbondioxide partial pressure（PaCO2）<45mmHg, liver:child-pugh class A - B and kidney: chronic kidney disease（CKD）stage 1-3);
5. receive under general anesthesia (including gynecology, orthopedics,general surgery and urology department).

Exclusion Criteria:

1. ASA>Ⅱ;
2. tumor patients
3. can't collaborate;