Effect of Antiviral Therapy on Host Immune in Patients With Chronic Hepatitis B Virus(HBV) Infection

Study the Effect of Nucleoside on Host Immune in Patients With CHB

During hepatitis B virus(HBV) infection host immune plays important role.Recently there are many different antiviral therapy methods.Different antiviral therapy methods showed different effector.In order to investigate whether these antiviral therapy methods especially methods directly inhibit viral replication have some effect on host immune the investigators designed these study. The investigators want to observe the change of host immune during antiviral therapy in patients with chronic HBV infection, and analyze the relationship between these changes and the antiviral effector of these drugs.

inclusion criteria:

• 18-65 years old
• chronic HBV infection
• HBeAg positive,HBV DNA more than 10E5 IU/mL
• ALT ≥2×UTL

exclusion criteria:

• with liver cancer
• with liver failure
• pregnant