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The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Herbs | Experimental | participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training |
|
| Placebo | Placebo Comparator | parcipants in this group will take placebo capsule containing microcrystalline cellulose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Eccentric exercise training | Behavioral | 12 weeks of lower leg eccentric training |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pulse Wave Velocity | PWV will be measured before, 6th week, 12th week of eccentric exercise training. | Before eccentric exercise and training |
| Pulse Wave Velocity | PWV will be measured before, 6th week, 12th week of eccentric exercise training. | 6th week of eccentric exercise traininig |
| Pulse Wave Velocity | PWV will be measured before, 6th week, 12th week of eccentric exercise training. | 12th week of eccentric exercise training |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention. | Before intervention |
| Blood pressure | Morning blood pressure will be measured before, 6th, and after 12 week of dietary and eccentric exercise intervention. |
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Inclusion Criteria:
-Healthy sedentary adults
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hsin-Fu Lin, Ph.D. | Contact | +886932873163 | hsinfu@ntu.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Hsin-Fu Lin, Ph.D | National Taiwan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University | Recruiting | Taipei | 106 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27912940 | Derived | Lin HF, Chou CC, Chao HH, Tanaka H. Panax ginseng and Salvia miltiorrhiza supplementation during eccentric resistance training in middle-aged and older adults: A double-blind randomized control trial. Complement Ther Med. 2016 Dec;29:158-163. doi: 10.1016/j.ctim.2016.10.003. Epub 2016 Oct 11. | |
| 27266702 | Derived |
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| 6th week of intervention |
| Blood pressure | Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention. | 12th week of intervention |
| Lin HF, Tung K, Chou CC, Lin CC, Lin JG, Tanaka H. Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial. BMC Complement Altern Med. 2016 Jun 6;16:168. doi: 10.1186/s12906-016-1139-4. |