Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of the study is to evaluate the acute effect of a standardized extract of KRG (Rg3-KRG) consisting of 30% total ginsenosides, including 10% Rg3 ginsenoside on arterial stiffness and blood pressure, as measured by the following parameters: aortic augmentation index, peripheral blood pressure, central blood pressure
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ginseng | Experimental | Encapsulated 400mg Rg3-KRG extract |
|
| Wheat Bran | Placebo Comparator | 400mg Wheat Bran capsule |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ginseng | Dietary Supplement | 400mg of encapsulated Rg3-KRG |
| |
| Wheat Bran |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the acute effect of Rg3-KRG on arterial stiffness in healthy adult volunteers, as measured by aortic augmentation index (AIx). | Two weeks (measurements taken on two separate visits with minimum one week washout) |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the acute effect of Rg3-KRG on aortic and brachial blood pressure in healthy adult volunteers. | Two weeks (measurements taken on two separate visits with minimum one week washout) |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the acute safety of Rg3-KRG in healthy adult volunteers using a 48hr symptoms questionnaire. | Two weeks |
Inclusion Criteria:
Main Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Dr. Vladimir Vuksan, PhD | Risk Factor Modification Centre - St. Michael's Hospital | Principal Investigator |
| Dr. Amir Hanna (Qualified investigator), MD | Unity Health Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Risk Factor Modification Centre, St. Michael's Hospital | Toronto | Ontario | M5B 1W8 | Canada |
Not provided
| ID | Term |
|---|---|
| C000713447 | Asian ginseng |
| D004043 | Dietary Fiber |
| ID | Term |
|---|---|
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Dietary Supplement |
400mg of encapsulated wheat bran |
|
| D010829 |
| Physiological Phenomena |
| D019602 | Food and Beverages |