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| Name | Class |
|---|---|
| Heart and Stroke Foundation of Canada | OTHER |
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Ginseng has been used for many years in a wide array of anecdotal medicinal properties. Animal and limited clinical research points to the vascular effects of Korean Red Ginseng (KRG). The present project aims to assess the efficacy of KRG and contribution of its factionated components on various indices of vascular function in healthy individuals. Our primary objective is to compare the acute effects of KRG and placebo on endothelial function. Moreover, our secondary objective is to evaluate the effect of isolated KRG factions on arterial stiffness, blood pressure and vasoactive markers. We hypothesize that (1) consumption of KRG will cause an improvement in endothelial function in healthy individuals, as compared to placebo; (2) consumption of KRG will cause an improvement in arterial stiffness and blood pressure in healthy individuals, as compared to placebo; (3) the ginsenoside faction of KRG is primarily responsible for the anticipated vascular effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Placebo Comparator | Placebo capsules (3g) |
|
| 2 | Experimental | Whole Korean Red Ginseng root (3g) |
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| 3 | Experimental | Ginsenoside fraction of Korean Red Ginseng B (0.22g); bioequivalent to the original whole KRG root |
|
| 4 | Experimental | Polysaccharide fraction of KRG root (0.21g); bioequivalent to the original whole KRG root |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Korean Red Ginseng | Dietary Supplement | Cultivated KRG-B (central body Korean Red Ginseng) obtained from Kyonggi-do Farm, Kyonggi-do Province, Korea. Dosage form: whole root in capsules (3g) |
| Measure | Description | Time Frame |
|---|---|---|
| Flow-mediated dilation of the brachial artery | Start and finish of each treatment arm |
| Measure | Description | Time Frame |
|---|---|---|
| Augmentation Index | Start and finish of each treatment arm | |
| Nitric Oxide and Cyclic GMP | Beginning of and 3 hours into clinical visit |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Vladimir Vuksan, PhD | St. Michael's Hospital, University of Toronto | Principal Investigator |
| Alexandra Jenkins, PhD | Unity Health Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Michael's Hospital Clinical Nutrition and Risk Factor Modification Centre | Toronto | Ontario | M5C 1N8 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24758417 | Background | Jovanovski E, Peeva V, Sievenpiper JL, Jenkins AL, Desouza L, Rahelic D, Sung MK, Vuksan V. Modulation of endothelial function by Korean red ginseng (Panax ginseng C.A. Meyer) and its components in healthy individuals: a randomized controlled trial. Cardiovasc Ther. 2014 Aug;32(4):163-9. doi: 10.1111/1755-5922.12077. | |
| 20134405 |
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|
| Korean Red Ginseng (Panax ginseng) | Dietary Supplement | Cultivated KRG-B (central body Korean Red Ginseng) obtained from Kyonggi-do Farm, Kyonggi-do Province, Korea. Dosage form: total ginsenoside fraction in capsules |
|
|
| Cornstarch | Dietary Supplement | Placebo |
|
| Korean Red Ginseng (Panax Ginseng) | Dietary Supplement | Cultivated KRG-B (central body Korean Red Ginseng) obtained from Kyonggi-do Farm, Kyonggi-do Province, Korea. Dosage form: total polysaccharide fraction (panaxans) in capsules |
|
|
| Jovanovski E, Jenkins A, Dias AG, Peeva V, Sievenpiper J, Arnason JT, Rahelic D, Josse RG, Vuksan V. Effects of Korean red ginseng (Panax ginseng C.A. Mayer) and its isolated ginsenosides and polysaccharides on arterial stiffness in healthy individuals. Am J Hypertens. 2010 May;23(5):469-72. doi: 10.1038/ajh.2010.5. Epub 2010 Feb 4. |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C000713447 | Asian ginseng |
| D013213 | Starch |
| ID | Term |
|---|---|
| D005936 | Glucans |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D011134 | Polysaccharides |
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