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The purpose of this study is to assess the effects of inhalation agent on corrected QT interval duration during liver transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sevoflurane | Performing liver transplantation under general anesthesia using sevoflurane |
| |
| Desflurane | Performing liver transplantation under general anesthesia using desflurane |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sevoflurane | Drug |
| ||
| Desflurane |
| Measure | Description | Time Frame |
|---|---|---|
| corrected QT interval (QTc interval) | up to 10 minutes after tracheal intubation, up to 60 minutes after reperfusion, at 10 minutes after hepatectomy, at 10 minutes after biliary anastomosis, at skin closure, at the arrival on ICU, on postoperative day 1. | up to postoperative day 1 after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| proportion of patients whose QTc interval is more than 450 ms for men and 470 ms for women | up to postoperative day 1 after surgery | |
| proportion of patients who have more than 500 ms of QTc interval | up to postoperative day 1 after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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subjects who were enrolled prospectively in study (ClinicalTrials.gov Identifier NCT01886664)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D000077335 | Desflurane |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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| Tp-e interval | up to 10 minutes after tracheal intubation, up to 60 minutes after reperfusion, at 10 minutes after hepatectomy, at 10 minutes after biliary anastomosis, at skin closure, at the arrival on ICU, on postoperative day 1. | up to postoperative day 1 after surgery |
| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D005019 | Ethyl Ethers |