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The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sevoflurane | Active Comparator | General Anesthesia procedure with sevoflurane |
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| desflurane | Active Comparator | General Anesthesia procedure with desflurane |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 12- derivation Electrocardiography | Diagnostic Test | 6 precordial and 4 extremity electrodes will be placed at appropriate anatomical points and a total of 6 12-lead ECGs will be taken at different anesthesia depths before anesthesia induction and throughout the operation. |
| Measure | Description | Time Frame |
|---|---|---|
| QTc T0 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR). | Baseline, preoperative |
| QTc T1 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR). | During surgery (at the time of the anesthesia induction) |
| QTc T2 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 0,6, it will be calculated from the ECG. | During surgery (at the time of MAC reached 0,6) |
| QTc T3 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1, it will be calculated from the ECG. | During surgery (at the time of MAC reached1) |
| QTc T4 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reaches 1,3 , it will be calculated from the ECG. | During surgery (at the time of MAC reached 1,3) |
| QTc T5 | QTc; It is calculated by dividing the QT interval by the square root of the RR interval (QTc= QT/ √RR).When the mac value reduces 0,3, it will be calculated from the ECG. | During surgery (at the time of MAC reduced 0,3) |
| iCEB T0 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| betül güven aytaç | Contact | +905073578351 | drbguven@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| ışıl karabeyoğlu | ankara ch bilkent | Principal Investigator |
| betül güven aytaç | Ankara CH bilkent | Study Chair |
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Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS)
| Baseline, preoperative |
| iCEB T1 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) | During surgery (at the time of the anesthesia induction) |
| iCEB T2 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 0,6, it will be calculated from the ECG. | During surgery (at the time of MAC reached 0,6) |
| iCEB T3 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1, it will be calculated from the ECG. | During surgery (at the time of MAC reached 1) |
| iCEB T4 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) the mac value reaches 1,3, it will be calculated from the ECG. | During surgery (at the time of MAC reached 1,3) |
| iCEB T5 | Index of cardio-electrophysiological balance (iCEB); calculated as QT distance divided by QRS duration (QT/ QRS) when the mac value reduces 0,3, it will be calculated from the ECG. | During surgery (at the time of MAC reduced 0,3) |