Comparison of Effect of Equi-MAC Anesthetics on PSI

Comparison of the Effect of Sevoflurane and Desflurane on Patient State Index: A Randomized Controlled Trial

The aim of this study is to compare the patient state index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent volatile anesthesia.

There have been several studies comparing electroencephalogram-derived indices produced by sevoflurane and desflurane. However, to the best of our knowledge, there has been no study which compared the two inhaled anesthetics using patient state index. Therefore, the aim of this study is to compare the patient state index values produced by sevoflurane and desflurane at equi-MAC in patients undergoing single-agent inhalation anesthesia.

Inclusion Criteria:

• patients aged between 19 and 65 yr
• patients with American Society of Anesthesiologists physical status classification I or II
• patients scheduled for elective surgery under volatile anesthesia
• patients obtaining written informed consent

Exclusion Criteria:

• patients with a history of any psychiatric or neurological disease
• patients receiving any medication affecting the autonomic or central nervous system
• patients with a history of alcohol or drug abuse
• pregnant or lactating women