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This study is a prospective observational study that analyzes the incidence of postoperative delirium in patients undergoing liver transplantation, based on the use of the inhalational anesthetic sevoflurane and the intravenous anesthetic propofol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sevoflurane Inhalation Anesthesia Group | Sevoflurane Inhalation Anesthesia Group in Liver Transplantation Patients | ||
| Propofol Intravenous Anesthesia Group | Propofol Intravenous Anesthesia Group in Liver Transplantation Patients |
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| Measure | Description | Time Frame |
|---|---|---|
| incidence of postoperative delirium | At least two times a day during the hospitalization period. Patients diagnosed with delirium using the CAM were evaluated for the duration, symptoms, and type of delirium (e.g., reduced awareness of the environment; poor cognitive skills; behavioral changes; and emotional disturbances). ** Confusion assessment methods(CAM) diagnostic algorism (positive or negative result, positive means delirium) CAM is considered positive if features 1 and 2 are present, with at least one of features 3 or 4. Below are the four criteria of features :
| from postoperative day 0 to postoperative day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| comprehensive geriatric assessment(CGA) | Core component of CGA are as follows : The Korean version of the fatigue, resistance, ambulation, illnesses, and loss of weight (K-FRAIL) scale : 0(healthy)~8(frail) Mini Nutritional Assessment(MNA) : 0 (malnutrition)~14(normal) Geriatric Depression Scale(GDS) : 0(normal)~ 15(depression) Instrumental Activities of Daily Living(IADL)-Lawton-Brody Scale : 0~8(complete independence) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine Yonsei University College of Medicine | Recruiting | Seoul | South Korea |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks |
| duration of delirium | Duration of Delirium: The duration of delirium is measured from the onset to the resolution of symptoms, recorded in hours or days (e.g., 1 day, 3 days, 5 days). | Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks |
| total score of QOR-40 | The Quality of Recovery-40 (QoR-40) 40~200(better recovery) | Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks |
| type of delirium | Type of Delirium: Delirium is classified into three types: hyperactive, hypoactive, and mixed. | Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |