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| Name | Class |
|---|---|
| Granit AS Transport & Tourism | OTHER |
| Norwegian Seafood Center | UNKNOWN |
| Nofima | OTHER |
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The investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults. A large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. Two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. In the present study the investigators will compare these fractions, by studying their effects on glucose regulation in overweight/obese adults.
Participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cod protein from presscake | Experimental |
| |
| Cod protein from presscake + stickwater | Experimental |
| |
| Control | Placebo Comparator | Control group will receive tablet containing only tablet fillers (the same as in the cod protein tablets). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cod protein from presscake | Dietary Supplement | 6g protein per day for 8wk |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose tolerance | Serum glucose will be measured in fasting and postprandial state | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Gene expression | Changes in gene expression in adipose tissue related to the circulating markers of glucose regulation. | 8 weeks |
| Amino acids and amino acid metabolites | Amino acids and amino acid metabolites will be measured in serum and urine |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Bergen | Bergen | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22647247 | Background | Vikoren LA, Nygard OK, Lied E, Rostrup E, Gudbrandsen OA. A randomised study on the effects of fish protein supplement on glucose tolerance, lipids and body composition in overweight adults. Br J Nutr. 2013 Feb 28;109(4):648-57. doi: 10.1017/S0007114512001717. Epub 2012 May 31. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| Cod protein from presscake + stickwater |
| Dietary Supplement |
6 g protein per day for 8 wk |
|
| Control | Dietary Supplement |
|
| 8 weeks |
| Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine | Concentrations of relevant metabolites and co-factors were measured in serum and urine | 8 weeks |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |