Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles

The Effect of Endometrial Injury on IVF Outcome Parameters in Patients With Repeated Implantation Failures

The iatrogenic induction of local endometrial injury caused through hysteroscopy or pipelle sampling in the preceding non- transfer cycle improves the IVF outcome parameters in patients with previous IVF failures.

Endometrial injury was preformed either through hysteroscope during office hysteroscopy through the non touch technique or through pipelle biopsy in the early follicular phase (days 5 to 9) in the preceding cycle of the IVF treatment.

Inclusion Criteria:

• Personal history of 2 or more failed IVF/ICSI cycles (RIF)
• Age</= 42 years
• Good response with good quality embryos in previous attempts (>2)

Exclusion Criteria:

• Personal history of endometrial tuberculosis/ antituberculous treatment
• Sonographically detected hydrosalpinges
• Intramural fibroids distorting the endometrial cavity, submucous myomas or Asherman's syndrome
• Thrombophilia