The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF

The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of Repeated Implantation Failure.

The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates

After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.

Inclusion Criteria:

• Women with RIF under 42 years old
• BMI 20-30
• Normal endometrial cavity
• FSH <15 IU/L
• Absence of immunological or hematological disorder

Exclusion Criteria:

• women over 42 years old
• FSH>15 IU/L
• women with chronic immunological or hematological disorder
• stage III or IV of endometriosis
• women with pathology concerning the endometrial cavity
• women with a medical history of adnexectomy or oophorectomy