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The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates
After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endometrial injury | Experimental | Endometrial injury before the embryo transfer of a frozen cycle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endometrial injury | Procedure | Endometrial injury was performed hysteroscopically after freeze all cycles and during the cycle before the frozen embryo transfer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Physiological parameter - Live birth rate | The complete expulsion or extraction from a woman of a product of fertilization, after 22 completed weeks of gestational age | 22 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Physiological parameter -Clinical pregnancy rate | A pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy | 7 weeks |
| Adverse event - Miscarriage |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Charalampos Siristatidis, Prof | National and Kapodistrian University of Athens | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National and Kapodistrian University of Athens | Athens | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27629122 | Background | Basile N, Garcia-Velasco JA. The state of "freeze-for-all" in human ARTs. J Assist Reprod Genet. 2016 Dec;33(12):1543-1550. doi: 10.1007/s10815-016-0799-9. Epub 2016 Sep 14. | |
| 12798877 | Background | Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5. |
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Endometrial injury in RIF patients
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Spontaneous loss of a clinical pregnancy before 22 completed weeks of gestational age
| 22 weeks |
| 28349510 | Background | Wong KM, van Wely M, Mol F, Repping S, Mastenbroek S. Fresh versus frozen embryo transfers in assisted reproduction. Cochrane Database Syst Rev. 2017 Mar 28;3(3):CD011184. doi: 10.1002/14651858.CD011184.pub2. |