Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle.We believe that the injury created causes release of substances which help in implantation.

Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF.

Patients will be randomly allotted to control and intervention group The patients in the intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior to IVF transfer cycle.

Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate.

SAMPLE SIZE: 100 PATIENTS (50 in each group).

Inclusion Criteria:

• Previous failed In-vitro fertilization embryo transfer cycle
• Patients who are good responders and have good quality embryos in the previous attempts
• Age of patients upto 37yrs

Exclusion Criteria:

• Those detected to have endometrial tuberculosis in the past, including those treated with Antituberculosis treatment
• Those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma
• Those with sonographically detected hydrosalpinx