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It was previously demonstrated in in vitro fertilization (IVF) patients that local injury of the endometrium during a spontaneous menstrual cycle that precedes IVF treatment doubled the rates of implantation and pregnancy. The hypothesis of our present study is that the endometrial injury procedure will have the same beneficial effect in patients undergoing controlled ovarian hyperstimulation (COH) combined with intrauterine insemination (IUI).
In order to test our hypothesis, we will perform the simple procedure of local injury of the endometrium using a "Pipelle" biopsy catheter during the spontaneous menstrual cycle that precedes a COH + IUI treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Clomiphene citrate + IUI + endometrial biopsy | Experimental | Clomiphene citrate + IUI + endometrial biopsy |
|
| Clomiphene citrate + IUI | No Intervention | ||
| gonadotrophines + IUI + endometrial biopsy | Experimental | two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment. |
|
| gonadotrophines + IUI | No Intervention | ||
| natural cycle + IUI + endometrail biopsy | Experimental | two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment. |
|
| natural cycle + IUI | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endometrial biopsy | Procedure | two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Pregnancy rate | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Live birth | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yuval Or, MD | Contact | +97289445150 | yuval_o@clalit.org.il | |
| Leila Aliger, MD | Contact | +97289445150 |
| Name | Affiliation | Role |
|---|---|---|
| Yuval Or, MD | Clalit health service | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Remez women medical center | Recruiting | Rehovot | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12798877 | Background | Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5. |
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| endometrial biopsy | Procedure | two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment. |
|
| natural cycle + IUI + endometrial biopsy | Procedure | two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment. |
|
| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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