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Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.
Low implantation rate is still a major concern in ART cycles. It has been reported that local injury to endometrium may improve endometrial receptivity and implantation rate. A total of 120 patients in first IVF cycles, who are stimulated with long protocol, are randomly divided into two groups. In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed and in the other group no interventions are done. After fresh embryo transfers, implantation and clinical pregnancy rates are compared between two groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| local ingury | Active Comparator | In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed. |
|
| control | No Intervention | in 60 patients routine IVF are performed |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| local injury | Procedure | In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed |
|
| Measure | Description | Time Frame |
|---|---|---|
| implantation rate | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy rate | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| homa oskouian, M.D. | Research and clinical center for infertility | Principal Investigator |
| Mohamad ali karimzade, MD | Research and clinical center for infertility | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research and clinical center for infertility | Yazd | Yazd Province | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34110001 | Derived | Lensen SF, Armstrong S, Gibreel A, Nastri CO, Raine-Fenning N, Martins WP. Endometrial injury in women undergoing in vitro fertilisation (IVF). Cochrane Database Syst Rev. 2021 Jun 10;6(6):CD009517. doi: 10.1002/14651858.CD009517.pub4. |
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