The Effects Of Remote Organ Ischemic Preconditioning On Systemic Inflammatory And Glycocalyx Integrity Parameters

The Effects Of Remote Organ Ischemic Preconditioning On Systemic Inflammatory And Glycocalyx Integrity Parameters In Living-Donor Liver Transplantation Patients

Ischemia-reperfusion (IR) injury during liver transplantation is one of the major causes of mortality and morbidity associated with transplantation. Remote organ ischemic preconditioning (RIPC) is one of the most investigated practices to reduce IR injury. In this study, for the first time in the clinic, the effect of RIPC will be evaluated via both systemic inflammation parameters and also parameters showing glycocalyx integrity, on living-donor liver recipients.

Inclusion Criteria:

• Patients followed up by Acıbadem Hospital Organ Transplantation Center
• Patients accepted to participate in the study
• Older than 18 years of age
• ASA class III
• MELD score >12
• Scheduled for elective liver transplantation surgery from a living donor

Exclusion Criteria:

• Patients undergoing re-transplantation
• Under the age of 18 years
• Patients undergoing emergency surgery
• Patients with hepatorenal or hepatopulmonary syndrome
• Patients receiving mechanical ventilation support in the ICU
• Patients refusing to participate