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The main goal of our project is to study and describe the effect of exercise training on systolic and diastolic myocardial function assessed by 2D ultrasound strain after myocardial infarction.
Our working hypothesis is that the intrinsic myocardial contractility and relaxation assessed by global longitudinal strain in phase II (or 2D strain) during post-infarction exercise training will be improved compared to baseline values as well as compared to values in a no-training group. Should this hypothesis prove true, it would help explain the improvements in functional capacity observed during the post-infarction period and after exercise training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise training | Experimental | Patients in this arm were encouraged to participate in an exercise training program, and they accepted to do so. Intervention: Cardiac training program |
|
| No exercise training | No Intervention | Patients in this arm were encouraged to participate in an exercise training program, and they refused to do so. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac training program | Other | This program takes place at the Cardiovascular Rehabilitation Department at the Nîmes University Hospital and includes a combination of various physical activities: treadmill, exercise bike, rower, aerobics, gymnastics, serious games, swimming. The program begins approximately within 3 months after myocardial infarction and consists of 20 consecutive days of training. The main physical activity is aerobic interval training (AIT). 30-minute AIT sessions will occur 5x per week for 4 weeks. 1 AIT session includes a warm up for 8 minutes to reach a heart rate during exercise corresponding to 20 to 30% of maximum aerobic power determined during the initial effort test. Then interval training occurs with 4x2 min of high intensity effort (heart rate during exercise corresponding to 80% of maximum aerobic power) alternating with 2 min of active recovery at 20-30% of maximum aerobic power. Then recovery for 8 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| The % global longitudinal strain of the left ventricle | within 3 months post infarction = T0 (baseline) | |
| The % global longitudinal strain of the left ventricle | 5 weeks | |
| The % global longitudinal strain of the left ventricle | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| maximal oxygen consumption (VO2max; mL/min/kg) | within 3 months post infarction = T0 (baseline) | |
| maximal oxygen consumption (VO2max; mL/min/kg) | T0 + 5 weeks | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Arnaud Dupeyron, MD, PhD | Centre Hospitalier Universitaire de NÄ«mes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nîmes - Hôpital Universitaire Carémeau | Nîmes | 30029 | France |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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|
| maximal oxygen consumption (VO2max; mL/min/kg) |
| T0 + 3 months |
| maximum aerobic power (watts) | within 3 months post infarction = T0 (baseline) |
| maximum aerobic power (watts) | T0 + 5 weeks |
| maximum aerobic power (watts) | T0 + 3 months |
| First ventilatory threshold (mL/min/kg) | within 3 months post infarction = T0 (baseline) |
| First ventilatory threshold (mL/min/kg) | T0 + 5 weeks |
| First ventilatory threshold (mL/min/kg) | T0 + 3 months |
| left ventricle longitudinal systolic strain rate | within 3 months post infarction = T0 (baseline) |
| left ventricle longitudinal systolic strain rate | T0 + 5 weeks |
| left ventricle longitudinal systolic strain rate | T0 + 3 months |
| left ventricle longitudinal diastolic strain rate | within 3 months post infarction = T0 (baseline) |
| left ventricle longitudinal diastolic strain rate | T0 + 5 weeks |
| left ventricle longitudinal diastolic strain rate | T0 + 3 months |
| % radial systolic strain | within 3 months post infarction = T0 (baseline) |
| % radial systolic strain | T0 + 5 weeks |
| % radial systolic strain | T0 + 3 months |
| % radial diastolic strain | within 3 months post infarction = T0 (baseline) |
| % radial diastolic strain | T0 + 5 weeks |
| % radial diastolic strain | T0 + 3 months |
| % circumferential systolic strain | within 3 months post infarction = T0 (baseline) |
| % circumferential systolic strain | T0 + 5 weeks |
| % circumferential systolic strain | T0 + 3 months |
| % circumferential diastolic strain | within 3 months post infarction = T0 (baseline) |
| % circumferential diastolic strain | T0 + 5 weeks |
| % circumferential diastolic strain | T0 + 3 months |
| Radial systolic strain rate | within 3 months post infarction = T0 (baseline) |
| Radial systolic strain rate | T0 + 5 weeks |
| Radial systolic strain rate | T0 + 3 months |
| Radial diastolic strain rate | within 3 months post infarction = T0 (baseline) |
| Radial diastolic strain rate | T0 + 5 weeks |
| Radial diastolic strain rate | T0 + 3 months |
| Circumferential systolic strain rate | within 3 months post infarction = T0 (baseline) |
| Circumferential systolic strain rate | T0 + 5 weeks |
| Circumferential systolic strain rate | T0 + 3 months |
| Circumferential diastolic strain rate | within 3 months post infarction = T0 (baseline) |
| Circumferential diastolic strain rate | T0 + 5 weeks |
| Circumferential diastolic strain rate | T0 + 3 months |
| Telediastolic volume (mL) | within 3 months post infarction = T0 (baseline) |
| Telesystolic volume (mL) | T0 + 5 weeks |
| Telesystolic volume (mL) | T0 + 3 months |
| Telediastolic volume (mL) | T0 + 5 weeks |
| Telediastolic volume (mL) | T0 + 3 months |
| Left ventricle mass (g/m^2) | within 3 months post infarction = T0 (baseline) |
| Left ventricle mass (g/m^2) | T0 + 5 weeks |
| Left ventricle mass (g/m^2) | T0 + 3 months |
| Ejection fraction of the left ventricle | within 3 months post infarction = T0 (baseline) |
| Ejection fraction of the left ventricle | T0 + 5 weeks |
| Ejection fraction of the left ventricle | T0 + 3 months |
| S' wave velocity (cm/s) | within 3 months post infarction = T0 (baseline) |
| S' wave velocity (cm/s) | T0 + 5 weeks |
| S' wave velocity (cm/s) | T0 + 3 months |
| E' wave velocity (cm/s) | within 3 months post infarction = T0 (baseline) |
| E' wave velocity (cm/s) | T0 + 5 weeks |
| E' wave velocity (cm/s) | T0 + 3 months |
| A' wave velocity (cm/s) | within 3 months post infarction = T0 (baseline) |
| A' wave velocity (cm/s) | T0 + 5 weeks |
| A' wave velocity (cm/s) | T0 + 3 months |
| The E/A ratio | within 3 months post infarction = T0 (baseline) |
| The E/A ratio | T0 + 5 weeks |
| The E/A ratio | T0 + 3 months |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |