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| Name | Class |
|---|---|
| Universidade do Porto | OTHER |
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Exercise training, as part of cardiac rehabilitation, is effective in improving functional capacity and quality of life in patients with coronary artery disease. Other cardiovascular and non-cardiovascular benefits have been reported, namely in glucose metabolism, skeletal muscle function, oxidative stress, vascular function, pulmonary circulation, ischaemia-reperfusion lesion and ventricular remodelling.
However, the benefit of exercise training on systolic and diastolic function is controversial especially after acute myocardial infarction where no longitudinal study has evaluated diastolic function using modern echocardiographic parameters.
The hypothesis is that a structured program of exercise training can improve systolic and diastolic function in patients after myocardial infarction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Standard of care | |
| Structured exercise training | Experimental | 8-week outpatient exercise-training program, encompassing 3 sessions per week, including endurance and resistance training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Structured exercise training | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial early diastolic velocity at mitral annulus by tissue Doppler (E' velocity) | Determined by echocardiography; results in cm/s | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Ratio between early diastolic filling velocity from mitral inflow and myocardial early diastolic velocity at mitral annulus by tissue Doppler (E/E' ratio) | Determined by echocardiography; no unit (ratio) | 4 months |
| Myocardial systolic velocity at mitral annulus by tissue Doppler (S' velocity) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Adelino Leite-Moreira, PhD | Universidade do Porto | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiology Department Gaia Hospital Center | Gaia | 4450-189 | Portugal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25872588 | Derived | Fontes-Carvalho R, Sampaio F, Teixeira M, Gama V, Leite-Moreira AF. The role of a structured exercise training program on cardiac structure and function after acute myocardial infarction: study protocol for a randomized controlled trial. Trials. 2015 Mar 12;16:90. doi: 10.1186/s13063-015-0612-6. |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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Determined by echocardiography; results in cm/s |
| 4 months |
| Left ventriclular ejection fraction | Determined by echocardiography; results in % | 4 months |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |